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Antimicrobial Protection with Flaminal®

Addressing hard to heal wounds and antimicrobial resistance in wound care

Hard to heal wounds are a significant challenge for healthcare systems worldwide. Infection is one of the most common complications that can delay or prevent healing. Misuse of antimicrobials has led to resistance, diminishing the effectiveness of many treatments. This antimicrobial resistance (AMR) increases morbidity, extends hospital stays, raises mortality rates, and drives up healthcare costs.

Flaminal® meets these critical needs by offering an effective solution that promotes wound healing with no recorded antimicrobial resistance to date. Its enzyme-based formula ensures optimal infection control without being cytotoxic to healthy skin cells, making it the ideal choice for achieving clinical outcomes in wound care.

Flaminal®supports the body’s natural wound healing response¹

Safe for skin cells

Flaminal® is non-cytotoxic, meaning it does not impede healthy skin cell growth.1

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No recorded AMR to date

Flaminal® provides antimicrobial protection with no recorded antimicrobial resistance (AMR) to date. 3,4

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Kills bacteria absorbed in the matrix

The antimicrobial effects of Flaminal® occur within its matrix.5

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Flaminal® mode of action

Flaminal® protects the wound from infection and biofilm. 2,3

Flaminal contains the GLG (glucose oxidase, lactoperoxidase and guaiacol ) system, which produces multiple reactive oxygen species (ROS) that can kill microbes in various ways, including disruption of cellular components and disrupting metabolic pathways to trigger cell death.

This multiple target approach from the ROS created is an effective way of reducing bioburden and to date has no recorded resistance. This unique antimicorbial action is also proven to reduce bacteria released from biofilms and prevent their reformation.

Flaminal®: advanced antimicrobial protection for optimal wound healing

1. Non-cytotoxic: supporting healthy cell growth without impeding healing

Flaminal®'s enzyme system is non-cytotoxic to new tissue, including keratinocytes and fibroblasts. This helps preserve healthy cells, promoting natural healing and reducing the risk of scarring. 6-8

2. No recorded Antimicrobial Resistance (AMR) to date 3,4

Flaminal® is an effective treatment for chronic wounds, offering protection against infection without the risk of antimicrobial resistance (AMR). Its enzyme-based formula promotes healing and has no bacterial resistance to date. So far, no evidence of AMR has been found with Flaminal®, making it a safe and trusted choice for wound care professionals and patients.

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3. Broad-spectrum bacteria elimination within 6 hours (In Vitro) 3

In vitro studies show that Flaminal® kills a broad range of bacteria within 6 hours, reducing bacterial load and lowering the risk of infection for natural healing. Its antimicrobial action makes it an effective treatment in managing wound infections caused by a wide range of pathogens.

Preventing biofilm formation

Flaminal® also protects against biofilm - bacterial clusters in a protective matrix found in about 78% of chronic wounds1,3. Biofilms can be highly resistant to antimicrobials and the body’s defenses, but Flaminal® reduces bacteria from biofilms and prevents their reformation, after sufficient mechanical debridement, providing superior infection control and improving healing outcomes.

Flaminal® is suitable for all stages in the wound infection continuum1

Flaminal® is an advanced wound care dressing designed to be effective across all stages of the wound infection phases.

Flaminal® supports healing while maintaining optimal moisture balance and controlling bacterial growth.

Its versatile, enzyme-based formula makes it a reliable solution for supporting wound healing and reducing bioburden at any stage of infection.

Discover more about Antimicrobial Resistance (AMR) and Antimicrobial Stewardship (AMS).

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Discover more about Flaminal® and its uses

Flaminal® is suitable for both acute and chronic wounds, infected* or those at risk of infection.

*under medical supervision only

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Discover the versatility of Flaminal® in wound care

Flaminal® is a versatile treatment for various wound types, sizes, shapes, and conditions, effective across all healing phases.

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Learn about Flaminal®'s easy application

Flaminal® provides continuous, effective care without product changes, with easy application and suitability for shared care to ensure uninterrupted healing.

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Additional resources

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Product information and resources

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Sources

  1. Swansen T et al., International Wound Infection Institute (IWII). Principles of Best Practice: Wound Infection in Clinical Practice. International Consensus Update 2016. Wounds International, 2016.
  2. Cooper RA (2013) Inhibition of biofilms by glucose oxidase, lactoperoxidase and guaiacol: the active antibacterial component in an enzyme alginogel. Int Wound J 10(6): 630–7. ​
  3. De Smet, K. et al. Pre-clinical evaluation of a new antimicrobial enzyme for the control of wound bioburden. Wounds. 2009, 21(3): 65-73.​
  4. Flen Health. Data on File. Internal Report: Evaluation of Fluid Absorption Capacity and Antimicrobial Activity of Aquacel products. 2017.
  5. Flen Health. Data on File. Internal Report: Evaluation of Fluid Absorption, Antimicrobial Activity and adherence to the wound bed of Cutimed sorbact. 2017.
  6. Hoeksema, H. et al. A comparative study of 1% silver sulphadiazine (Flammazine®) versus an enzyme alginogel (Flaminal®) in the treatment of partial thickness burns. Burns. 2013, 39(6): 1234-1241.
  7. Deitch EA, Wheelahan TM, Rose MP, Clothier J, Cotter J. ‘Hypertrophic burn scars: analysis of variables.’ The journal of trauma 1983 Vol.23 No 10. page 895-8.
  8. Evidence for the link between healing time and the development of hypertrophic scars (HTS) in paediatric burns due to scald injury. Cubison TC, Pape SA, Parkhouse N. Burns 2006, vo. 32, nr 8 p 992-9